Antibiotic resistance management

Antibiotic resistance management

Antibiotic resistance management Andrew F. Read and Robert J. Woods Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802, USA and Division of Infectious Diseases, University of Michigan, Ann Arbor, MI 48109, USA *Corresponding author. Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802, USA. Tel:+81...

Part VI. Antibiotic management and resistance in livestock production.

Antibiotic Resistance

Antibiotic resistance is an ongoing evolutionary process that has been the concern of infectious disease specialists since antibiotic use gained popularity. Antibiotic resistance is not a concern of the public as reflected by their desire for antibiotics whenever illness occurs. Patients can and do pressure their physicians for antibiotics ; 12 million antibiotic prescriptions were filled for u...

Management of antibiotic resistance in the intensive care unit setting.

Over the past few decades, an alarming increase of infections caused by antibiotic-resistant pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus species, carbapenem-resistant Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp., and multidrug-resistant Acinetobacter spp., has been observed, partic...

Evolution of Antibiotic Resistance without Antibiotic Exposure

Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evol...